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Monte Carlo simulation of PET images for injection doseoptimization

Journal Article

Boldyš Jiří, Dvořák Jiří, Skopalová M., Bělohlávek O.

serial: International Journal for Numerical Methods in Biomedical Engineering vol.29, 9 (2013), p. 988-999

project(s): 1M0572, GA MŠk

keywords: positron emission tomography, Monte Carlo simulation, biological system modeling, image quality

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abstract (eng):

When a patient is examined by positron emission tomography (PET), radiotracer dose amount (activity) has to be determined. However, the rules for activity correction according to patients’ weight used nowadays do not correspond with practical experience. Very high image quality is achieved for slim patients, whereas noisy images are produced for obese patients. There is opportunity to modify the correction rule with the aim to equalize image quality within the broad spectrum of patients and to diminish radiation risk to slim patients, with special importance for children. We have built a model of a particular PET scanner and approximated human trunk, which is our region of interest, by a cylindrical model with segments of liver, outer adipose tissue, and the rest. We have performed Monte Carlo simulations of PET imaging using the GATE simulation package. Under reasonably simplifying assumptions and for special parameters.


21.12.2012 - 16:10