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Conference Paper (international conference)

Mathematics and Optimal control theory meet Pharmacy: Towards application of special techniques in modeling, control and optimization of biochemical networks

Papáček Štěpán, Matonoha Ctirad, Duintjer Tebbens Jurjen

: Proceedings of the SNA'21 Seminar on Numerical Analysis Modelling and Simulation of Challenging Engineering Problems, p. 60-63 , Eds: Starý Jiří, Sysala Stanislav

: SNA'21 Seminar on Numerical Analysis Modelling and Simulation of Challenging Engineering Problems (SNA'21 2021), (Ostrava, CZ, 20210125)

: GA19-05872S, GA ČR

: Dynamical system, Systems pharmacology, Biochemical network, Input-output regulation, Optimization

: http://www.ugn.cas.cz/event/2021/sna/files/sna21-sbornik.pdf

(eng): Similarly to other scienti c domains, the expenses related to in silico modeling in pharmacology need not be extensively apologized. Vis a vis both in vitro and in vivo experiments, physiologically-based pharmacokinetic (PBPK) and pharmacodynamic models represent an important tool for the assessment of drug safety before its approval, as well as a viable option in designing dosing regimens. In this contribution, some special techniques related to the mathematical modeling, control and optimization of biochemical networks are presented on a paradigmatic example of enzyme kinetics.

: BC

: 20205

07.01.2019 - 08:39