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Journal Article

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation

Wrobel A.G., Kadlecova Z., Kamenický Jan, Yang J.C., Herrmann T., Kelly B.T., McCoy A.J., Evans P.R., Martin S., Muller S., Šroubek Filip, Neuhaus D., Honing S., Owen D.J.

: Developmental Cell vol.50, 4 (2019), p. 494-508

: GA18-05360S, GA ČR

: clathrin-coated pit, NECAP protein

: 10.1016/j.devcel.2019.07.017



(eng): Wrobel et al. show that phosphorylation of the mammalian endocytic AP2 adaptor causes a conformational change that allows it to efficiently bind the protein NECAP. This, in turn, recruits membrane-remodeling proteins into clathrin-coated pits, which drive their formation toward final scission from the parent membrane.

: JD

: 20206