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Research Report

Bayesian Selective Transfer Learning for Patient-Specific Inference in Thyroid Radiotherapy

Murray Sean Ernest, Quinn Anthony

: ÚTIA AV ČR, (Praha 2020)

: Research Report 2388

: GA18-15970S, GA ČR

: Bayesian estimation, thyroid carcinoma, patient-specific inferences

: http://library.utia.cas.cz/separaty/2021/AS/quinn-0538241.pdf

(eng): This research report outlines a selective transfer approach for Bayesian estimation of patient-specific levels of radioiodine activity in the thyroid during the treatment of differentiated thyroid carcinoma. The work seeks to address some limitations of previous approaches [4] which involve generic, non-selective transfer of archival data. It is proposed that improvements in patient-specific inferences may be achieved via transferring external population knowledge selectively. This involves matching the patient to a similar sub-population based on available metadata, generating a Gaussian Mixture Model within the partitioned data, and optimally transferring a data predictive distribution from the sub-population to the specific patient. Additionally, a performance evaluation method is proposed and early-stage results presented.

: BD

: 10102